Abstract
The placebo effect can be defined as any improvement of illnesses or reduction of subjective symptoms
that result from interventions possessing no known physical effects. By contrast,
the nocebo effect refers to undesirable symptoms or illnesses that follow interventions also lacking
known physical effects. It may also play a role in chronic illnesses that lack objective
confirmation. Both placebo and nocebo effects can be potent and must be understood
by both practitioners and researchers for proper application in clinical medicine.
Individual caregivers can apply these principles to modify results in the daily care
of patients.
Keywords
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References
- The placebo effect: the good, the bad, and the ugly.Am J Med. 2014; 127: 484-488
- Reconsidering the placebo response from a broad anthropological perspective.Cult Med Psychiatry. 2009; 33: 112-152
- The nocebo effect of drugs.Pharmacol Res Perspect. 2016; 4: e00208
- Placebo Effects: Understanding the Mechanisms in Health and Disease.Oxford University Press, New York2009
- The nocebo effect: a clinician's guide.Aust N Z J Psychiatry. 2013; 47: 617-623
- Rapid overview of systematic reviews of nocebo effects reported by patients taking placebos in clinical trials.Trials. 2018; 19: 674
- Nocebo in clinical trials for depression: a meta-analysis.Psychiatry Res. 2013; 215: 82-86
- Nocebo in Alzheimer's disease; meta-analysis of placebo-controlled clinical trials.J Neurol Sci. 2015; 355: 94-100
- The contribution of suggestibility and expectation to placebo analgesia phenomenon in an experimental setting.Pain. 2002; 96: 393-402
- Commercial features of placebo and therapeutic efficacy.JAMA. 2008; 299: 1016-1017
- Differential effectiveness of placebo treatments. a systematic review of migraine prophylaxis.JAMA Intern Med. 2013; 173: 1941-1951
- Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos.J Neurol. 2000; 247: 183-188
- The placebo and nocebo phenomena: their clinical management and impact on treatment outcomes.Clin Ther. 2017; 39: 477-486
- How often do general practitioners use placebos and non-specific interventions. Systematic review and meta-analysis of surveys.PLoS One. 2018; 13e0202211
- Questionnaire survey on use of placebos.BMJ. 2004; 329: 944-946
- Academic physicians use placebos in clinical practice and believe in the mind-body connection.J Gen Intern Med. 2007; 23: 7-10
- Frequency of adverse events in the placebo arms of COVID-19 vaccine trials. A systematic review and meta-analysis.JAMA Netw Open. 2022; 5e2143955
- Rapid overview of systematic reviews of nocebo effects reported by patients taking placebos in clinical trials.Trials. 2018; 19: 674
- Somatic symptom disorders without known physical causes: one disease with many names?.Am J Med. 2015; 128: 1054-1058
- Strategies for managing fibromyalgia.Am J Med. 2009; 122: S31-S43
- Acupuncture for treating fibromyalgia.Cochrane Database Syst Rev. 2013; 2013CD007070
- The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials.Clin Rheumatol. 2017; 36: 1623-1630
- Acupuncture for ‘frequent attenders’ with medically unexplained symptoms: a randomised controlled trial (CACTUS study).Br J Gen Pract. 2011; 61: e295-e305
Article Info
Publication History
Published online: July 08, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: None.
Conflicts of Interest: None.
Authorship: The sole author is responsible for all content.
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