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In Plain Sight: An Inconspicuous Case of a Giant Cell Tumor

      A 37-year-old Jamaican man presented to the Emergency Department for 2 months of increasing fatigue, left thigh pain, and difficulty ambulating. He had been living in the United States for the past 2 years. His medical history included iron deficiency anemia diagnosed in 2008 during a work health examination. He was placed on ferrous sulfate tablets without any additional work-up performed. At that time, he had been living in Jamaica and worked as a cruise ship chef. A year prior to presentation, he had undergone a single blood transfusion, which he attributed to his iron deficiency anemia.
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      References

        • Sobti A
        • Agrawal P
        • Agarwala S
        • Agarwal M
        Giant cell tumor of bone - an overview.
        Arch Bone Jt Surg. 2016; 4: 2-9
        • Palmerini E
        • Picci P
        • Reichardt P
        • Downey G
        Malignancy in giant cell tumor of bone: a review of the literature.
        Technol Cancer Res Treat. 2019; 181533033819840000
        • Turcotte RE
        Giant cell tumor of bone.
        Orthop Clin North Am. 2006; 37: 35-51
        • Chakarun CJ
        • Forrester DM
        • Gottsegen CJ
        • Patel DB
        • White EA
        • Matcuk Jr, GR
        Giant cell tumor of bone: review, mimics, and new developments in treatment.
        Radiographics. 2013; 33: 197-211
        • McGrath PJ
        Giant-cell tumour of bone: an analysis of fifty-two cases.
        J Bone Joint Surg Br. 1972; 54: 216-229
        • Puthoor D
        • Iype W
        Giant cell tumor: curettage and bone grafting.
        Indian J Orthop. 2007; 41: 121-123
        • Jamshidi K
        • Gharehdaghi M
        • Hajialiloo SS
        • Mirkazemi M
        • Ghaffarzadehgan K
        • Izanloo A
        Denosumab in patients with giant cell tumor and its recurrence: a systematic review.
        Arch Bone Jt Surg. 2018; 6: 260-268
        • Hengyuan Li
        • Junjie G
        • Nong L
        • Minghao Z
        • Zhaoming Y
        Denosumab in giant cell tumor of bone: current status and pitfalls.
        Front Oncol. 2020; 10580605
        • Tse LF
        • Wong KC
        • Kumta SM
        • Huang L
        • Chow TC
        • Griffith JF
        Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study.
        Bone. 2008; 42: 68-73
        • Rutkowski P
        • Ferrari S
        • Grimer RJ
        • et al.
        Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone.
        Ann Surg Oncol. 2015; 22: 2860-2868
        • van Langevelde K
        • McCarthy CL
        Radiological findings of denosumab treatment for giant cell tumours of bone.
        Skeletal Radiol. 2020; 49: 1345-1358