Abstract
Background
Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have
been proposed to lower the risk of Parkinson disease by reducing oxidative stress
based on animal and in vitro studies. Thus, this study aimed to test this association
in patients with newly diagnosed hypertension.
Methods
This retrospective cohort study enrolled 107,207 patients with newly diagnosed hypertension
between 2001 and 2013. The hazard ratios for Parkinson disease were calculated for
ARB treatment compared with those who never used ARBs and among the 5 subgroups receiving
different cumulative ARB dosages.
Results
We identified 527 (1.1%) Parkinson disease cases among patients with ARB treatment
in a median observation period of 8.4 years compared to the 1,255 (2.2%) Parkinson
disease cases among those without ARB treatment in a median observation period of
6.8 years. Overall, risk for developing Parkinson disease was statistically lower
in the ARB-treated group with a hazard ratio of 0.56 (95% confidence interval: 0.51-0.63)
than those without ARB.
Conclusions
ARB treatment was associated with a statistically important reduction of Parkinson
disease risk in patients with newly diagnosed hypertension. Therefore, ARB may constitute
an effective neuroprotective strategy to lower Parkinson disease risk in such patients.
Keywords
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Article Info
Publication History
Published online: May 14, 2022
Footnotes
Funding: None.
Conflicts of Interest: None.
Authorship: All authors had access to the data and a role in writing this manuscript.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
