Takotsubo cardiomyopathy is a generally reversible syndrome of acute cardiac failure
usually triggered by a physical or emotional stressor, with unique left ventricular
(LV) wall motion abnormalities and no association with obstructive coronary artery
disease.
1
,
2
,
3
The presentation mimics acute coronary syndrome, with chest pain or dyspnea and abnormal
electrocardiogram (ECG) and cardiac injury markers. We present a case of reverse (or
inverted) Takotsubo cardiomyopathy (rTTC) following kidney transplantation in a 69-year-old
woman. In addition to end-stage renal disease, the patient's medical history included
depression, anxiety disorder, chronic nausea, hypertension, dyslipidemia, and gastroesophageal
reflux disease. She had been receiving long-term hemodialysis twice weekly. Other
therapy included corticosteroids for immunosuppression, pravastatin 20 mg daily, and
clonidine 0.1 mg twice daily. Prior coronary angiography in preparation for kidney
transplant revealed mild nonobstructive coronary artery disease.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy.J Am Coll Cardiol. 2010; 55: 333-411
- Clinical features and outcomes of Takotsubo (stress) cardiomyopathy.N Engl J Med. 2015; 373: 929-938
- Current state of knowledge on Takotsubo syndrome: a position statement from the task force on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology.Eur J Fail. 2016; 18: 8-27
- Differences between Takotsubo cardiomyopathy and reverse Takotsubo cardiomyopathy associated with subarachnoid hemorrhage.Int J Cardiol Heart Vasc. 2016; 11: 99-103
- An emotional stress as a trigger for reverse Takotsubo cardiomyopathy. A case report and literature review.Am J Case Rep. 2016; 17: 137-142
- Differences in the clinical profile and outcomes of typical and atypical Takotsubo syndrome: data from the International Takotsubo Registry.JAMA Cardiol. 2016; 1: 335-340
- Reverse Takotsubo cardiomyopathy: a comprehensive review.Ann Transl Med. 2018; 6: 460-466
- Mechanisms of acute mitral regurgitation in patients with Takotsubo cardiomyopathy. An Echocardiographic Study.Circ Cardiovasc Imaging. 2011; 4: 392-398
Article Info
Publication History
Published online: February 04, 2022
Robert G. Stern, MD, Section EditorFootnotes
Funding: None.
Conflicts of Interest: All authors declare that they have no conflicts of interest.
Authorship: All authors had access to the data and participated in writing the manuscript.
Identification
Copyright
Published by Elsevier Inc.
