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Funding: This work was supported by National Institutes of Health grants AG06945 , HL62508 , and DK088195 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Conflicts of Interest: None.
Authorship: XS, PK, CJL, and JZ have given substantial contributions to the conception or the design of the manuscript; PHP, MG, and XS to analysis and interpretation of the data. All authors have participated in drafting and critically revising the manuscript. All authors read and approved the final version of the manuscript.