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Requests for reprints should be addressed to Eric Denes, MD, Infectious Diseases Department, ELSAN Polyclinique de Limoges, 18 rue du Général Catroux, 87000 Limoges, France.
A 75-year-old man had a replacement of his tibia, due to a primary bone sarcoma, with
a silver-coated megaprosthesis (Figure, A). At 3-year follow-up, he presented with gray-blue colored skin overlying the
prosthesis (Figure, B). This indicated release of silver from the prosthesis and a diagnosis of localized
argyria. There was no clinical consequence of this colored skin. Unfortunately, in
the follow-up, he presented with an infection of this megaprosthesis. After several
attempts to treat this infection, he asked for an amputation.
Figure(A) Radiography of patient lower limbs with the silver-coated megaprosthesis. (B) Skin aspect 3 years after prosthesis implantation.
Authorship: All authors had access to the data and participated in the management of the patient and the preparation of the manuscript. ED wrote the manuscript, FF and SEB made corrections, and all authors approved the final version of the manuscript.
