Local Argyria due to Silver-Coated Megaprosthesis

Published:February 05, 2022DOI:
      A 75-year-old man had a replacement of his tibia, due to a primary bone sarcoma, with a silver-coated megaprosthesis (Figure, A). At 3-year follow-up, he presented with gray-blue colored skin overlying the prosthesis (Figure, B). This indicated release of silver from the prosthesis and a diagnosis of localized argyria. There was no clinical consequence of this colored skin. Unfortunately, in the follow-up, he presented with an infection of this megaprosthesis. After several attempts to treat this infection, he asked for an amputation.
      Figure(A) Radiography of patient lower limbs with the silver-coated megaprosthesis. (B) Skin aspect 3 years after prosthesis implantation.
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