A 75-year-old man had a replacement of his tibia, due to a primary bone sarcoma, with a silver-coated megaprosthesis (Figure, A). At 3-year follow-up, he presented with gray-blue colored skin overlying the prosthesis (Figure, B). This indicated release of silver from the prosthesis and a diagnosis of localized argyria. There was no clinical consequence of this colored skin. Unfortunately, in the follow-up, he presented with an infection of this megaprosthesis. After several attempts to treat this infection, he asked for an amputation.
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Published online: February 05, 2022Uma Paniker, MD, Section Editor
Conflicts of Interest: None.
Authorship: All authors had access to the data and participated in the management of the patient and the preparation of the manuscript. ED wrote the manuscript, FF and SEB made corrections, and all authors approved the final version of the manuscript.
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