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Guide to the female student athlete ECG: A comprehensive study of 3466 young, racially diverse athletes

      Highlights

      • Sex specific criteria for athlete ECG interpretation is needed
      • The addition of age, race, and ethnicity can provide nuanced ECG interpretation
      • Future guidelines may want to include extremes of RS voltage as abnormalities

      ABSTRACT

      Objectives

      : The 12-lead electrocardiogram (ECG) is used in the preparticipation screening exam for athletes. Despite known differences in ECG findings by sex, only QTc prolongation is given a sex specific threshold. We hypothesize that our large dataset – with diversity in age, race, and sport participation – can be utilized to improve ECG screening in female student athletes.

      Methods

      : Computerized 12-lead ECGs were recorded and analyzed in female athletes who underwent preparticipation screening exam between 06/2010 and 09/2021. The quantitative, empirical 2017 international criteria for electrocardiographic interpretation were compared to either the 99th percentile in our cohort or the percentile that corresponded to the known disease prevalence.

      Results

      : Of 3466 female athletes with ECGs as part of preparticipation screening exam, the 2017 international criteria classified 2.1% of athletes with at least one ECG abnormality requiring cardiological evaluation. Rates were similar across age, race/ethnicity, and sporting discipline. Using ranges based on our population, 2.7% of athletes would require additional workup. Surprisingly, ST depression up to 0.03 mV was a normal finding in this cohort. If RS voltage extremes were considered findings requiring follow up, an additional 9.6% of the athlete population would be flagged using current definitions. This number decreases to 2.7% if using the 99th percentile in this cohort.

      Conclusion

      : These results highlight a difference in the reported prevalence of ECG abnormalities when comparing empirically derived thresholds to statistically derived ranges. Consideration of new metrics specific to the female athlete population has the potential to further refine athlete ECG screening.

      Keywords

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      REFERENCES

        • Fagard R.
        Athlete's heart.
        Heart. 2003; 89: 1455-1461https://doi.org/10.1136/heart.89.12.1455
        • Myerburg RJ
        • Vetter VL.
        Electrocardiograms should be included in preparticipation screening of athletes.
        Circulation. 2007; 116 (discussion 2626): 2616-2626https://doi.org/10.1161/CIRCULATIONAHA.107.733519
        • Uberoi A
        • Stein R
        • Perez MV
        • et al.
        Interpretation of the electrocardiogram of young athletes.
        Circulation. 2011; 124: 746-757https://doi.org/10.1161/CIRCULATIONAHA.110.013078
        • Drezner JA
        • Sharma S
        • Baggish A
        • et al.
        International criteria for electrocardiographic interpretation in athletes: Consensus statement.
        Br J Sports Med. 2017; 51: 704-731https://doi.org/10.1136/bjsports-2016-097331
        • Corîci OM
        • Mirea-Munteanu O
        • Donoiu I
        • Istrătoaie O
        • Corîci CA
        • Iancău M.
        Gender-Related Electrocardiographic Changes in Athletes.
        Curr Health Sci J. 2018; 44: 29-33https://doi.org/10.12865/CHSJ.44.01.05
        • Fuller CM.
        Cost effectiveness analysis of screening of high school athletes for risk of sudden cardiac death.
        Med Sci Sports Exerc. 2000; 32: 887-890https://doi.org/10.1097/00005768-200005000-00002
        • D'Ascenzi F
        • Biella F
        • Lemme E
        • Maestrini V
        • Di Giacinto B
        • Pelliccia A.
        Female Athlete's Heart.
        Circ Cardiovasc Imaging. 2020; 13e011587https://doi.org/10.1161/CIRCIMAGING.120.011587
        • Di Paolo FM
        • Pelliccia A.
        The “Athlete's Heart”: Relation to Gender and Race.
        Cardiol Clin. 2007; 25: 383-389https://doi.org/10.1016/j.ccl.2007.06.010
        • Drezner JA
        • Owens DS
        • Prutkin JM
        • et al.
        Electrocardiographic Screening in National Collegiate Athletic Association Athletes.
        Am J Cardiol. 2016; 118: 754-759https://doi.org/10.1016/j.amjcard.2016.06.004
        • Janssens K
        • Paratz E
        • Brosnan M
        • et al.
        You've got to be in it to win it: the importance of including female athletes in screening ECG cohorts.
        Eur Heart J. 2020; 41 (ehaa946.3136)https://doi.org/10.1093/ehjci/ehaa946.3136
        • Rawlins J
        • Carre F
        • Kervio G
        • et al.
        Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes.
        Circulation. 2010; 121: 1078-1085https://doi.org/10.1161/CIRCULATIONAHA.109.917211
        • Finocchiaro G
        • Dhutia H
        • D'Silva A
        • et al.
        Effect of Sex and Sporting Discipline on LV Adaptation to Exercise.
        JACC Cardiovasc Imaging. 2017; 10: 965-972https://doi.org/10.1016/j.jcmg.2016.08.011
        • Rao SJ
        • Shah AB.
        Exercise and the Female Heart.
        Clin Ther. 2022; 44: 41-49https://doi.org/10.1016/j.clinthera.2021.11.018
        • Harmon KG
        • Asif IM
        • Klossner D
        • Drezner JA.
        Incidence of sudden cardiac death in National Collegiate Athletic Association athletes.
        Circulation. 2011; 123: 1594-1600https://doi.org/10.1161/CIRCULATIONAHA.110.004622
        • Maron BJ
        • Doerer JJ
        • Haas TS
        • Tierney DM
        • Mueller FO.
        Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006.
        Circulation. 2009; 119: 1085-1092https://doi.org/10.1161/CIRCULATIONAHA.108.804617
        • Corrado D
        • Basso C
        • Rizzoli G
        • Schiavon M
        • Thiene G.
        Does sports activity enhance the risk of sudden death in adolescents and young adults?.
        Journal of the American College of Cardiology. 2003; 42: 1959-1963https://doi.org/10.1016/j.jacc.2003.03.002
        • Christiansen SL
        • Iverson C
        • Flanagin A
        • Livingston EH
        • Fischer L
        • Manno C.
        AMA Manual of Style: A Guide for Authors and Editors.
        Oxford University Press, 2020 (JAMA Network)
        • Mango F
        • Caselli S
        • Luchetti A
        • Pelliccia A.
        Low QRS voltages in Olympic athletes: Prevalence and clinical correlates.
        Eur J Prev Cardiol. 2020; 27: 1542-1548https://doi.org/10.1177/2047487320914758
        • Maron BJ.
        Sudden death in young athletes.
        N Engl J Med. 2003; 349: 1064-1075https://doi.org/10.1056/NEJMra022783
        • Eckart RE
        • Scoville SL
        • Shry EA
        • Potter RN
        • Tedrow U.
        Causes of sudden death in young female military recruits.
        Am J Cardiol. 2006; 97: 1756-1758https://doi.org/10.1016/j.amjcard.2006.01.036
        • Colombo CSSS
        • Finocchiaro G.
        The Female Athlete's Heart: Facts and Fallacies.
        Curr Treat Options Cardiovasc Med. 2018; 20: 101https://doi.org/10.1007/s11936-018-0699-7
        • Sharma S
        • Papadakis M.
        Interpreting the Athlete's EKG: are all repolarization anomalies created equal?.
        Circulation. 2015; 131: 128-130https://doi.org/10.1161/CIRCULATIONAHA.114.013739
        • Schnell F
        • Riding N
        • O'Hanlon R
        • et al.
        Recognition and significance of pathological T-wave inversions in athletes.
        Circulation. 2015; 131: 165-173https://doi.org/10.1161/CIRCULATIONAHA.114.011038
        • Papadakis M
        • Carre F
        • Kervio G
        • et al.
        The prevalence, distribution, and clinical outcomes of electrocardiographic repolarization patterns in male athletes of African/Afro-Caribbean origin.
        Eur Heart J. 2011; 32: 2304-2313https://doi.org/10.1093/eurheartj/ehr140
        • Maron BJ.
        Hypertrophic cardiomyopathy: an important global disease.
        Am J Med. 2004; 116: 63-65https://doi.org/10.1016/j.amjmed.2003.10.012
      1. Cavarretta E, Sciarra L, Biondi-Zoccai G, et al. Age-Related Electrocardiographic Characteristics of Male Junior Soccer Athletes. Front Cardiovasc Med. 2021;8:784170. doi:10.3389/fcvm.2021.784170

        • Santini M
        • Di Fusco SA
        • Colivicchi F
        • Gargaro A.
        Electrocardiographic characteristics, anthropometric features, and cardiovascular risk factors in a large cohort of adolescents.
        EP Europace. 2018; 20: 1833-1840https://doi.org/10.1093/europace/euy073
        • Goldberger AL.
        Normal and noninfarct Q waves.
        Cardiol Clin. 1987; 5: 357-366
        • Riding NR
        • Sharma S
        • McClean G
        • Adamuz C
        • Watt V
        • Wilson MG.
        Impact of geographical origin upon the electrical and structural manifestations of the black athlete's heart.
        Eur Heart J. 2019; 40: 50-58https://doi.org/10.1093/eurheartj/ehy521
      2. Yeo TJ, Wang M, Grignani R, et al. Electrocardiographic and Echocardiographic Insights From a Prospective Registry of Asian Elite Athletes. Front Cardiovasc Med. 2021;8:799129. doi:10.3389/fcvm.2021.799129

        • Sheikh N
        • Papadakis M
        • Ghani S
        • et al.
        Comparison of electrocardiographic criteria for the detection of cardiac abnormalities in elite black and white athletes.
        Circulation. 2014; 129: 1637-1649https://doi.org/10.1161/CIRCULATIONAHA.113.006179
        • Ashley EA
        • Raxwal VK
        • Froelicher VF.
        The prevalence and prognostic significance of electrocardiographic abnormalities.
        Curr Probl Cardiol. 2000; 25: 1-72https://doi.org/10.1016/s0146-2806(00)70020-x
        • Hsieh BP
        • Pham MX
        • Froelicher VF.
        Prognostic value of electrocardiographic criteria for left ventricular hypertrophy.
        Am Heart J. 2005; 150: 161-167https://doi.org/10.1016/j.ahj.2004.08.041
        • Saguner AM
        • Ganahl S
        • Baldinger SH
        • et al.
        Usefulness of electrocardiographic parameters for risk prediction in arrhythmogenic right ventricular dysplasia.
        Am J Cardiol. 2014; 113: 1728-1734https://doi.org/10.1016/j.amjcard.2014.02.031
        • De Lazzari M
        • Zorzi A
        • Cipriani A
        • et al.
        Relationship Between Electrocardiographic Findings and Cardiac Magnetic Resonance Phenotypes in Arrhythmogenic Cardiomyopathy.
        J Am Heart Assoc. 2018; 7e009855https://doi.org/10.1161/JAHA.118.009855
        • Schwartz PJ
        • Stramba-Badiale M
        • Crotti L
        • et al.
        Prevalence of the congenital long-QT syndrome.
        Circulation. 2009; 120: 1761-1767https://doi.org/10.1161/CIRCULATIONAHA.109.863209
        • Priori SG
        • Napolitano C
        • Schwartz PJ.
        Low penetrance in the long-QT syndrome: clinical impact.
        Circulation. 1999; 99: 529-533https://doi.org/10.1161/01.cir.99.4.529
        • Priori SG
        • Schwartz PJ
        • Napolitano C
        • et al.
        Risk stratification in the long-QT syndrome.
        N Engl J Med. 2003; 348: 1866-1874https://doi.org/10.1056/NEJMoa022147
        • Moss AJ
        • Schwartz PJ
        • Crampton RS
        • et al.
        The long QT syndrome. Prospective longitudinal study of 328 families.
        Circulation. 1991; 84: 1136-1144https://doi.org/10.1161/01.cir.84.3.1136
        • Maron Barry J.
        • Zipes Douglas P.
        Introduction: Eligibility recommendations for competitive athletes with cardiovascular abnormalities—general considerations.
        J Am Coll Cardiol. 2005; 45: 1318-1321https://doi.org/10.1016/j.jacc.2005.02.006
        • Johnson JN
        • Ackerman MJ.
        QTc: how long is too long?.
        Br J Sports Med. 2009; 43: 657-662https://doi.org/10.1136/bjsm.2008.054734
        • Hadley D
        • Hsu D
        • Pickham D
        • Drezner JA
        • Froelicher VF.
        QT Corrections for Long QT Risk Assessment: Implications for the Preparticipation Examination.
        Clin J Sport Med. 2019; 29: 285-291https://doi.org/10.1097/JSM.0000000000000522