Supplementary Table 2Complete Case Analysis and Fully Conditional Specification Imputation Multivariable Fine-Gray Regressions for Recurrent Infective Endocarditis in Persons Who Inject Drugs with Consideration for Death as a Competing Risk
Complete Case Analysis Fully Conditional Specification
SHR* Robust Std. Err. 95% CI P Value SHR* Std. Err. 95% CI P Value
Age 1.00 0.01 0.97 1.03 0.92 1.00 0.14 0.97 1.03 0.92
Sex (ref = female) 1.37 0.42 0.75 2.50 0.31 1.18 0.34 0.67 2.06 0.56
Length of hospital stay 1.00 0.002 1.00 1.01 0.60 1.00 0.002 1.00 1.01 0.71
Left-sided or bilateral infection or echo-negative (ref = right-sided IE) 0.57 0.21 0.28 1.18 0.13 0.60 0.20 0.30 1.16 0.13
Peripherally inserted central catheter misuse (ref = no misuse)
 Peripherally inserted central catheter misused 2.41 0.89 1.17 4.98 0.02 2.63 0.89 1.36 5.09 0.004
 No peripherally inserted central catheter in place 0.27 0.30 0.03 2.26 0.23 0.17 0.18 0.21 1.37 0.10
Referral to addiction services (ref = not referred) 1.49 0.41 0.87 2.55 0.15 1.69 0.43 1.02 2.78 0.04
Surgical intervention (ref = no surgery) 1.16 0.45 0.54 2.50 0.70 1.19 0.42 0.59 2.39 0.63
Admission to the ICU (ref = not admitted) 1.04 0.36 0.53 2.04 0.91 1.19 0.36 0.67 2.14 0.55
Misuse of Opiates and Stimulants (ref = opiate or stimulant use only) 0.85 0.26 0.47 1.54 0.60 0.85 0.25 0.49 1.50 0.59
Antibiotic administration (ref=intravenous)
 Oral 0.93 0.36 0.44 2.00 0.86 0.86 0.31 0.43 1.75 0.69
 Other† 0.35 0.35 0.05 2.54 0.30 0.65 0.49 0.15 2.89 0.57
Treatment (ref = inpatient)
 Outpatient 2.02 0.61 1.12 3.66 0.02 1.71 0.50 0.97 3.04 0.07
 Left against medical advice 1.49 0.71 0.58 3.78 0.41 1.51 0.68 0.62 3.67 0.37
Homelessness (ref=not homeless) 1.43 0.70 0.55 3.71 0.46 1.54 0.75 0.59 3.99 0.38
Values in bold indicate statistical significance (P<0.05).
Abbreviations: CCA, complete case analysis; SHR, sub-distribution hazard ratio; Std. Err., standard error; CI, confidence interval; ICU, intensive care unit.
⁎ Adjusted SHRs were generated from multivariable Fine-Gray regression models. The multivariable model was adjusted for age, sex, length of hospital stay, location of infection, peripherally inserted central catheter misuse, referral to addiction services, surgical intervention, ICU admission, substances misused, route of antibiotic administration, inpatient treatment, and homelessness.
† Intramuscular or oral and intravenous.